Multi-walled carbon nanotubes enhanced fungal colonization and suppressed innate immune response to fungal infection in nematodes.

ABSTRACT: The underlying molecular mechanisms for multi-walled carbon nanotube (MWCNT)-induced in vivo toxicity on innate immunity are still largely unclear. Considering the potential of Caenorhabditis elegans for the study of innate immune response of animals, we employed this in vivo assay system to investigate the effects of MWCNTs on innate immune response of animals and the underlying mechanisms. Pre-exposure to MWCNTs at concentrations more than 100 μg L^-1 enhanced the adverse effect of fungal infection in reducing lifespan. With regard to the underlying cellular mechanisms, we found that MWCNT pre-exposure enhanced colony formation of Candida albicans in the body of nematodes, and suppressed innate immune response of nematodes by decreasing expression le

SUBMITTER: Shakoor S 

PROVIDER: S-EPMC6062404 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature