Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway.

ABSTRACT: Prior to forming and refining synaptic connections, axons of projection neurons navigate long distances to their targets. While much is known about guidance cues for axon navigation through intermediate choice points, whether and how axons are organized within tracts is less clear. Here we analyze the organization of retinal ganglion cell (RGC) axons in the developing mouse retinogeniculate pathway. RGC axons are organized by both eye-specificity and topography in the optic nerve and tract: ipsilateral RGC axons are segregated from contralateral axons and are offset laterally in the tract relative to contralateral axon topographic position. To identify potential cell-autonomous factors contributing to the segregation of ipsilateral and contralateral RGC axons in the visual pathway, we asse

SUBMITTER: Sitko AA 

PROVIDER: S-EPMC6062437 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature