Regulation of the activins-follistatins-inhibins axis by energy status: Impact on reproductive function.

ABSTRACT:

Background

We have previously demonstrated that the adipose tissue derived hormone leptin controls reproductive function by regulating the hypothalamic-pituitary-gonadal axis in response to energy deficiency. Here, we evaluate the activins-follistatins-inhibins (AFI) axis during acute (short-term fasting in healthy people) and chronic energy deficiency (women with hypothalamic amenorrhea due to strenuous exercise [HA]) and investigate their relation to leptin and reproductive function in healthy subjects and subjects with HA.

Methods

The AFI axis was investigated in: a) A double-blinded study in healthy subjects having three randomly assigned admissions, each time for four days: in the isocaloric fed state, complete fasting with placebo treatment, complete fasting with lepti

SUBMITTER: Perakakis N 

PROVIDER: S-EPMC6062472 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature