Ontology highlight
ABSTRACT:
SUBMITTER: Otchere ID
PROVIDER: S-EPMC6062541 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20180726 1
Mycobacterium africanum (Maf) causes a substantial proportion of human tuberculosis in some countries of West Africa, but little is known on this pathogen. We compared the genomes of 253 Maf clinical isolates from Ghana, including N = 175 Lineage 5 (L5) and N = 78 Lineage 6 (L6). We found that the genomic diversity of L6 was higher than in L5 despite the smaller sample size. Regulatory proteins appeared to evolve neutrally in L5 but under purifying selection in L6. Even though over 90% of the hu ...[more]