Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics.

ABSTRACT: High-quality, 25 nm octahedral-shaped Fe₃O₄ magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe₃O₄-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T₂ relaxivity for magnetic resonance imaging as compared to other types of Fe₃O₄-Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe₃O₄-Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanopar

SUBMITTER: Efremova MV 

PROVIDER: S-EPMC6062557 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature