The Synergistic Effect of Exogenous Glutamine and Rifampicin Against Mycobacterium Persisters.

ABSTRACT: Persisters, stochastic dormant variants of normal bacteria cell, represent a significant portion of the survivors upon exposure to antibiotics and other environmental stresses, which contributes substantially to high level antibiotics tolerance. Glutamine is a crucial component of the Mycobacteria nitrogen pool that is indispensable for survival upon stresses. To study whether a synergistic effect exists between glutamine and antibiotics against Mycobacterial persisters, the efficacy of rifampicin alone or together with exogenous glutamine upon Mycobacterium smegmatis mc² 155 persisters was monitored. The result showed that glutamine decreases M. smegmatis tolerance to rifampicin upon starvation. The reactive oxygen species level of the strains treate

SUBMITTER: Huang X 

PROVIDER: S-EPMC6062616 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature