Disruption of Adipokinetic Hormone Mediated Energy Homeostasis Has Subtle Effects on Physiology, Behavior and Lipid Status During Aging in Drosophila.

ABSTRACT: The impact of disruption of adipokinetic hormone (AKH) signaling was studied during aging in Drosophila in a sexually dimorphic manner. A mutant (Akh¹) producing a non-functional AKH peptide was compared with isogenized wild-type controls (w¹¹¹⁸), and Akh-rescue line where AKH was ectopically expressed in the mutant background (EE-Akh). Longevity, fecundity, and locomotor activity rhythms remained unaffected by lack of AKH signaling. While the strength of rhythms declined in general with age across all fly lines tested this was more so in case of Akh¹ flies. Negative geotaxis was significantly impaired in Akh¹ flies. Only young Akh¹ flies of both sexes and old Akh¹

SUBMITTER: Bednarova A 

PROVIDER: S-EPMC6062650 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature