Human CD49a⁺ Lung Natural Killer Cell Cytotoxicity in Response to Influenza A Virus.

ABSTRACT: Influenza A virus (IAV) is a major global public health burden due to its routine evasion of immunization strategies. Natural killer (NK) cells are innate cytotoxic cells with important antiviral activity in the human body, yet the function of these cells in the control of IAV infection is unclear. The aim of this study was to determine the role of lung NK cell cytotoxic responses to IAV. Human lung explants were infected ex vivo with IAV, and lung NK cell activation was analyzed by flow cytometry. Cytotoxic responses of NK cell subsets against IAV-infected macrophages were measured by flow cytometry and ELISA. Despite reports of hypofunctionality in the pulmonary environment, human lung-associated NK cells responded rapidly to ex vivo IAV infection, with upregulation of surf

SUBMITTER: Cooper GE 

PROVIDER: S-EPMC6062652 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature