Cumulative evidence for relationships between multiple variants of HNF1B and the risk of prostate and endometrial cancers.

ABSTRACT:

Background

To provide a synopsis of the current understanding of the association between variants of HNF1B and cancer susceptibility, we conducted a comprehensive research synopsis and meta-analysis to evaluate associations between HNF1B variants and prostate and endometrial cancers.

Results

Eighteen studies totaling 34,937 patients and 55,969 controls were eligible for this meta-analysis. Four variants showed a significant association with the risk of individual cancer. Strong significant associations were found between rs4430796 A and the risk of both prostate cancer (OR = 1.247, p = 2.21 × 10^- 77) and endometrial cancer (OR = 1.217, p = 8.98 × 10^- 16); the AA, AG genotypes also showed strong significant associations with the risk of prostate cancer (

SUBMITTER: Tong Y 

PROVIDER: S-EPMC6062884 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature