ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms.

ABSTRACT: Expression of human Apolipoprotein E (APOE) modulates the inflammatory response in an isoform specific manner, with APOE4 isoform eliciting a stronger pro-inflammatory response, suggesting a possible mechanism for worse outcome following traumatic brain injury (TBI). APOE lipidation and stability is modulated by ATP-binding cassette transporter A1 (ABCA1), a transmembrane protein that transports lipids and cholesterol onto APOE. We examined the impact of Abca1 deficiency and APOE isoform expression on the response to TBI using 3-months-old, human APOE3^+/+ (E3/Abca1^+/+) and APOE4^+/+ (E4/Abca1^+/+) targeted replacement mice, and APOE3^+/+ and APOE4^+/+ mice with only one functional copy of the Abca1 gene (E3/Abca1^+/-;

SUBMITTER: Castranio EL 

PROVIDER: S-EPMC6062955 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature