Lower respiratory tract microbial composition was diversified in Pseudomonas aeruginosa ventilator-associated pneumonia patients.

ABSTRACT:

Background

Probiotics could prevent Pseudomonas aeruginosa colonization in lower respiratory tract (LRT) and reduced P. aeruginosa ventilator-associated pneumonia (VAP) rate. Recent studies also suggested that probiotics could improve lung inflammation in mice infected with P. aeruginosa. It seems that microbiota regulation may be a potential therapy for P. aeruginosa VAP patients. However, we know less about the LRT microbial composition and its correlation with prognosis in P. aeruginosa VAP patients. This study aimed to characterize LRT microbiota in P. aeruginosa VAP patients and explore the relationship between microbiota and patient prognosis.

Methods

Deep endotracheal secretions were sampled from subjects via intubation. Communities were identified by 16S ribosomal RN

SUBMITTER: Qi X 

PROVIDER: S-EPMC6062970 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature