Insight into Notch Signaling Steps That Involve pecanex from Dominant-Modifier Screens in Drosophila.

ABSTRACT: Notch signaling plays crucial roles in intercellular communications. In Drosophila, the pecanex (pcx) gene, which encodes an evolutionarily conserved multi-pass transmembrane protein, appears to be required to activate Notch signaling in some contexts, especially during neuroblast segregation in the neuroectoderm. Although Pcx has been suggested to contribute to endoplasmic reticulum homeostasis, its functions remain unknown. Here, to elucidate these roles, we performed genetic modifier screens of pcx We found that pcx heterozygotes lacking its maternal contribution exhibit cold-sensitive lethality, which is attributed to a reduction in Notch signaling at decreased temperatures. Using sets of deletions that uncover most of the second and third chromosomes, we identified four enhancers and

SUBMITTER: Yamakawa T 

PROVIDER: S-EPMC6063225 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature