Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease.

ABSTRACT: Disease phenotypes can be highly variable among individuals with the same pathogenic mutation. There is increasing evidence that background genetic variation is a strong driver of disease variability in addition to the influence of environment. To understand the genotype-phenotype relationship that determines the expressivity of a pathogenic mutation, a large number of backgrounds must be studied. This can be efficiently achieved using model organism collections such as the Drosophila Genetic Reference Panel (DGRP). Here, we used the DGRP to assess the variability of locomotor dysfunction in a LRRK2 G2019S Drosophila melanogaster model of Parkinson's disease (PD). We find substantial variability in the LRRK2 G2019S locomotor phenotype in different DGRP backgrounds. A genome-wide associatio

SUBMITTER: Lavoy S 

PROVIDER: S-EPMC6063243 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature