Functional Impact of the H2A.Z Histone Variant During Meiosis in Saccharomyces cerevisiae.

ABSTRACT: Among the collection of chromatin modifications that influence its function and structure, the substitution of canonical histones by the so-called histone variants is one of the most prominent actions. Since crucial meiotic transactions are modulated by chromatin, here we investigate the functional contribution of the H2A.Z histone variant during both unperturbed meiosis and upon challenging conditions where the meiotic recombination checkpoint is triggered in budding yeast by the absence of the synaptonemal complex component Zip1 We have found that H2A.Z localizes to meiotic chromosomes in an SWR1-dependent manner. Although meiotic recombination is not substantially altered, the htz1 mutant (lacking H2A.Z) shows inefficient meiotic progression, impaired sporulation, and reduced spo

SUBMITTER: Gonzalez-Arranz S 

PROVIDER: S-EPMC6063244 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature