Biological Processes Modulating Longevity across Primates: A Phylogenetic Genome-Phenome Analysis.

ABSTRACT: Aging is a complex process affecting different species and individuals in different ways. Comparing genetic variation across species with their aging phenotypes will help understanding the molecular basis of aging and longevity. Although most studies on aging have so far focused on short-lived model organisms, recent comparisons of genomic, transcriptomic, and metabolomic data across lineages with different lifespans are unveiling molecular signatures associated with longevity. Here, we examine the relationship between genomic variation and maximum lifespan across primate species. We used two different approaches. First, we searched for parallel amino-acid mutations that co-occur with increases in longevity across the primate linage. Twenty-five such amino-acid variants were identified, se

SUBMITTER: Muntane G 

PROVIDER: S-EPMC6063263 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature