Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish.

ABSTRACT: Signal gradients encode instructive information for numerous decision-making processes during embryonic development. A striking example of precise, scalable tissue-level patterning is the segmentation of somites-the precursors of the vertebral column-during which the fibroblast growth factor (FGF), Wnt, and retinoic acid (RA) pathways establish spatial gradients. Despite decades of studies proposing roles for all three pathways, the dynamic feature of these gradients that encodes instructive information determining segment sizes remained elusive. We developed a non-elongating tail explant system, integrated quantitative measurements with computational modeling, and tested alternative models to show that positional information is encoded solely by spatial fold change (SFC) in FGF signal out

SUBMITTER: Simsek MF 

PROVIDER: S-EPMC6063364 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature