Ontology highlight
ABSTRACT:
SUBMITTER: Hassannia B
PROVIDER: S-EPMC6063467 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20180625 8
High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism. WA dose-dependently either activates the nuclear factor-like 2 pathway through targeting of Kelch-like ECH-associated protein 1 (noncanonical ferroptosis induction) or inactivates glutathione peroxidase 4 (canonical ferroptosis induction). Noncanonical ferroptosis ...[more]