Antimullerian hormone as a risk factor for miscarriage in naturally conceived pregnancies.

ABSTRACT: OBJECTIVE:To determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies. DESIGN:Prospective cohort study. SETTING:Not applicable. PATIENT(S):Women (n = 533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Miscarriage, defined as an intrauterine pregnancy loss before 20 weeks' gestation. RESULT(S):After adjusting for maternal age, race, history of recurrent miscarriage, and obesity, risk of miscarriage decreased as AMH increased (risk ratio per unit increase in natural log of AMH = 0.83; 95% confidence interval [CI], 0.73, 0.94). Women with severely diminished ovarian reserve (AMH ? 0.4 ng/mL) miscarried at over twice the rate of women with an AMH ? 1 ng/mL (hazard ratio, 2.3; 95% CI, 1.3, 4.3). CONCLUSION(S):AMH levels are inversely associated with the risk of miscarriage. Women with severely diminished ovarian reserve are at an increased risk of miscarriage.

SUBMITTER: Lyttle Schumacher BM 

PROVIDER: S-EPMC6063511 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature