The Startle-Evoked Potential: Negative Affect and Severity of Pathology in Anxiety/Mood Disorders.

ABSTRACT:

Background

The National Institute of Mental Health Research Domain Criteria initiative encourages a search for dimensional biological measures of psychopathology unconstrained by current diagnostic categories. Consistent with this aim, the presented research studies a large sample of anxiety and mood disorder patients, assessing differences in principal diagnoses and comorbidity patterns, clinicians' ratings, and questionnaire measures of negative affect and life dysfunction as they relate to a potential brain marker of pathology: the amplitude of the event-related potential (ERP) elicited by a startle-evoking stimulus.

Methods

Patients seeking evaluation or treatment for anxiety and mood disorders (N = 208) participated in two tasks at the University of Florida (Gainesville

SUBMITTER: Lang PJ 

PROVIDER: S-EPMC6063515 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature