Quantitative performance and optimal regularization parameter in block sequential regularized expectation maximization reconstructions in clinical ⁶⁸Ga-PSMA PET/MR.

ABSTRACT:

Background

In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and ¹⁸F-FDG PET reported higher signal-to-noise ratios and higher standardized uptake values (SUV). In this study, we investigate the optimal regularization parameter (β) for clinical ⁶⁸Ga-PSMA PET/MR reconstructions in the pelvic region applying time-of-flight (TOF) BSREM in comparison to TOF OSEM. Two-minute emission data from the pelvic region of 25 patients who underwent ⁶⁸Ga-PSMA PET/MR were retrospectively reconstructed. Reference OSEM reconstructions

SUBMITTER: Ter Voert EEGW 

PROVIDER: S-EPMC6063806 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature