Biomechanics and mechanical signaling in the ovary: a systematic review.

ABSTRACT:

Purpose

Mammalian oogenesis and folliculogenesis share a dynamic connection that is critical for gamete development. For maintenance of quiescence or follicular activation, follicles must respond to soluble signals (growth factors and hormones) and physical stresses, including mechanical forces and osmotic shifts. Likewise, mechanical processes are involved in cortical tension and cell polarity in oocytes. Our objective was to examine the contribution and influence of biomechanical signaling in female mammalian gametogenesis.

Methods

We performed a systematic review to assess and summarize the effects of mechanical signaling and mechanotransduction in oocyte maturation and folliculogenesis and to explore possible clinical applications. The review identified 2568 publications

SUBMITTER: Shah JS 

PROVIDER: S-EPMC6063820 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature