Detachment of ligands from nanoparticle surface under flow and endothelial cell contact: Assessment using microfluidic devices.

ABSTRACT: Surface modification of nanoparticles is a well-established methodology to alter their properties to enhance circulation half-life. While literature studies using conventional, in vitro characterization are routinely used to evaluate the biocompatibility of such modifications, relatively little attention has been paid to assess the stability of such surface modifications in physiologically relevant conditions. Here, microfluidic devices were used to study the effect of factors that adversely impact surface modifications including vascular flow and endothelial cell interactions. Camptothecin nanoparticles coated with polyethylene glycol (PEG) and/or folic acid were analyzed using linear channels and microvascular networks. Detachment of PEG was observed in cell-free conditions and was attri

SUBMITTER: Jarvis M 

PROVIDER: S-EPMC6063868 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature