Liver blood dynamics after bariatric surgery: the effects of mixed-meal test and incretin infusions.

ABSTRACT: AIMS/HYPOTHESIS:The mechanisms for improved glycemic control after bariatric surgery in subjects with type 2 diabetes (T2D) are not fully known. We hypothesized that dynamic hepatic blood responses to a mixed-meal are changed after bariatric surgery in parallel with an improvement in glucose tolerance. METHODS:A total of ten morbidly obese subjects with T2D were recruited to receive a mixed-meal and a glucose-dependent insulinotropic polypeptide (GIP) infusion before and early after (within a median of less than three months) bariatric surgery, and hepatic blood flow and volume (HBV) were measured repeatedly with combined positron emission tomography/MRI. Ten lean non-diabetic individuals served as controls. RESULTS:Bariatric surgery leads to a significant decrease in weight, accompanied w

SUBMITTER: Honka H 

PROVIDER: S-EPMC6063878 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature