An integrative omics approach to unravel toxicity mechanisms of environmental chemicals: effects of a formulated herbicide.

ABSTRACT: The use of integrative molecular approaches can aid in a comprehensive understanding of the effects of toxicants at different levels of biological organization, also supporting risk assessment. The present study aims to unravel the toxicity mechanisms of a widely used herbicide to the arthropod Folsomia candida exposed in a natural soil, by linking effects on reproduction, proteomics and genome-wide gene expression. The EC50 effects on reproduction over 4 weeks was 4.63 mg glyphosate/kg of soil. The formulation included a polyethoxylated tallowamine as an adjuvant, which at 50% effect on reproduction had an estimated concentration of 0.87-1.49 mg/kg of soil. No effects were observed on survival and reproduction when using the isolated active substance, pointing the toxicity of the formulat

SUBMITTER: Simoes T 

PROVIDER: S-EPMC6063884 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature