Progesterone Receptors in Prostate Cancer: Progesterone receptor B is the isoform associated with disease progression.

ABSTRACT: The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone's role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms (PGRA, PGRB) in PCa tissue and their association with clinical endpoints. This was conducted retrospectively by collecting radical prostatectomy specimens from 535 patients. Tissue was analyzed using tissue microarray, where representative tumor areas were carefully selected. Protein expression was evaluated through immunohistochemistry, in stromal and epithelial tissue. Associations between recepto

SUBMITTER: Grindstad T 

PROVIDER: S-EPMC6063894 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature