Precoce and opposite response of proteasome activity after acute or chronic exposure of C. elegans to γ-radiation.

ABSTRACT: Species are chronically exposed to ionizing radiation, a natural phenomenon which can be enhanced by human activities. The induced toxicity mechanisms still remain unclear and seem depending on the mode of exposure, i.e. acute and chronic. To better understand these phenomena, studies need to be conducted both at the subcellular and individual levels. Proteins, functional molecules in organisms, are the targets of oxidative damage (especially via their carbonylation (PC)) and are likely to be relevant biomarkers. After exposure of Caenorhabditis elegans to either chronic or acute γ rays we showed that hatching success is impacted after acute but not after chronic irradiation. At the molecular level, the carbonylated protein level in relation with dose was slightly different between acute a

SUBMITTER: Dubois C 

PROVIDER: S-EPMC6063909 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature