Inflammatory response of microglia to prions is controlled by sialylation of PrP^Sc.

ABSTRACT: Neuroinflammation is recognized as one of the obligatory pathogenic features of neurodegenerative diseases including Alzheimer's, Parkinson's or prion diseases. In prion diseases, space and time correlations between deposition of disease-associated, pathogenic form of the prion protein or PrP^Sc and microglial-mediated neuroinflammation has been established. Yet, it remains unclear whether activation of microglia is triggered directly by a contact with PrP^Sc, and what molecular features of PrP^Sc microglia sense and respond to that drive microglia to inflammatory states. The current study asked the questions whether PrP^Sc can directly trigger activation of microglia and whether the degree of microglia response depends on the nature of terminal carb

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC6063910 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature