Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis.

ABSTRACT:

Background

Human arylamine N-acetyltransferase 2 (NAT2) gene has a key role in xenobiotic metabolism through the conjugation of acetyl group to xenobiotic substances. NAT2 has been suggested as a susceptibility factor in endometriosis; however, the results of studies have been controversial. In this study, the association of NAT2 polymorphisms with susceptibility to endometriosis was evaluated in an Iranian population.

Methods

This is an association study and totally 141 women with diagnosis of endometriosis and 158 healthy women as control group were analyzed for NAT2 gene polymorphisms (C481T, A803G, G857A and G590A) by PCR-RFLP methods.

Results

The 590 GA genotype was significantly lower (p=0.001; OR=0.42, 95% CI: 0.25-0.71) in the patie

SUBMITTER: Fayez D 

PROVIDER: S-EPMC6064003 | biostudies-literature | 2018 Jul-Sep

REPOSITORIES: biostudies-literature