CD36 - a plausible modifier of disease phenotype in familial adenomatous polyposis.

ABSTRACT:

Background

Familial adenomatous polyposis (FAP) is a well characterised genetic predisposition to early onset colorectal cancer (CRC) that is characterised by polyposis of the colon and rectum. Animal models have consistently suggested the role of modifier genes in determining disease phenotype, yet none have been substantiated in the human population. The mouse homologue of cluster of differentiation 36 (CD36) has been proposed as a modifier of disease in the MIN mouse model of FAP.

Methods

Three single nucleotide polymorphisms (SNPs); rs1049673, rs1761667 and rs1984112 in CD36, have been investigated in 275 FAP patients to determine if they were associated with age of polyposis or risk of developing disease.

Results

The results revealed a substa

SUBMITTER: Holmes M 

PROVIDER: S-EPMC6064055 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature