Classification of gallbladder cancer by assessment of CD8⁺ TIL and PD-L1 expression.

ABSTRACT:

Background

Programmed death ligand 1/2 (PD-L1/PD-L2) expression has been established as a prognostic factor for various solid tumors and as a predictive factor for PD-1 blockade therapy, but scant data on its role in gallbladder cancer (GBC). The aims of this study were to assess the expression of PD-L1/PD-L2 and the density of CD8⁺ tumor-infiltrating lymphocytes (TIL) from GBC samples and to quantify the association between survival prognosis and these factors.

Methods

CD8⁺ TILs density and the expression of PD-1, PD-L1, PD-L2 and CD133 were assessed using immunohistochemistry in tumor specimens from 66 patients with gallbladder adenocarcinoma. These indexes were correlated with the clinicopathological features.

Results

The rate of PD-L1-positiv

SUBMITTER: Lin J 

PROVIDER: S-EPMC6064069 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature