A case of Naegleria fowleri related primary amoebic meningoencephalitis in China diagnosed by next-generation sequencing.

ABSTRACT:

Background

Primary amoebic meningoencephalitis (PAM), caused by Naegleria fowleri, is a rare protozoan infectious disease in China. A fatality rate of over 95% had been reported due to extremely rapid disease progression in the USA and other countries. Rapid and precise identification of the causative agent is very important to clinicians for guiding their choices for administering countermeasures in the clinic. In this report, we applied the next-generation sequencing (NGS) method to rapidly show that N. fowleri was the causative agent of a fatal case involving a 42-year-old man with severe PAM disease, the first reported in mainland China.

Case presentation

A 42-year old male in a deep coma was admitted to Shenzhen Third People's Hospital, a special medical care unit with

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6064090 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature