Assessing imprecision in Cochrane systematic reviews: a comparison of GRADE and Trial Sequential Analysis.

ABSTRACT:

Background

The evaluation of imprecision is a key dimension of the grading of the confidence in the estimate. Grading of Recommendations Assessment, Development and Evaluation (GRADE) gives recommendations on how to downgrade evidence for imprecision, but authors vary in their use. Trial Sequential Analysis (TSA) has been advocated for a more reliable assessment of imprecision. We aimed to evaluate reporting of and adherence to GRADE and to compare the assessment of imprecision of intervention effects assessed by GRADE and TSA in Cochrane systematic reviews.

Methods

In this cross-sectional study, we included 100 Cochrane reviews irrespective of type of intervention with a key dichotomous outcome meta-analyzed and assessed by GRADE. The methods and results sections of each re

SUBMITTER: Castellini G 

PROVIDER: S-EPMC6064621 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature