Sex steroids mediate discrete effects on HDL cholesterol efflux capacity and particle concentration in healthy men.

ABSTRACT:

Background

Exogenous testosterone decreases serum concentrations of high-density lipoprotein cholesterol (HDL-C) in men, but whether this alters cardiovascular risk is uncertain.

Objective

To investigate the effects of testosterone and estradiol on HDL particle concentration (HDL-Pima) and metrics of HDL function.

Methods

We enrolled 53 healthy men, 19 to 55 years of age, in a double-blinded, placebo-controlled, randomized trial. Subjects were rendered medically castrate using the GnRH receptor antagonist acyline and administered either (1) placebo gel, (2) low-dose transdermal testosterone gel (1.62%, 1.25 g), (3) full replacement dose testosterone gel (1.62%, 5 g) or (4) full replacement dose testosterone gel together with an aromatase inhibitor for 4 weeks. At base

SUBMITTER: Rubinow KB 

PROVIDER: S-EPMC6064653 | biostudies-literature | 2018 Jul - Aug

REPOSITORIES: biostudies-literature