Family History in the Primary Open-Angle African American Glaucoma Genetics Study Cohort.

ABSTRACT:

Purpose

To determine the relationship between positive family history (FH) and primary open-angle glaucoma (POAG) diagnosis and clinical presentation in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) cohort.

Methods

FH of POAG in first-degree relatives was assessed in 2365 subjects in the POAAGG cohort. A standardized interview was used to assess FH of glaucoma, demographic characteristics, lifestyle choices, and medical and ocular comorbidities.

Results

Positive FH was associated with increased risk of POAG (age-adjusted odds ratio and 95% confidence interval 3.4 [2.8, 4.1]). In age-adjusted analysis among POAG cases, positive FH was associated with younger age (P < .001), female sex (P < .001), hypertension (P = .006), use of hypertension medicat

SUBMITTER: O'Brien JM 

PROVIDER: S-EPMC6064667 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature