Secreted Phospholipases A₂ in Hereditary Angioedema With C1-Inhibitor Deficiency.

ABSTRACT:

Background

Hereditary angioedema (HAE) caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) is a disabling, potentially fatal condition characterized by recurrent episodes of swelling. We have recently found that patients with C1-INH-HAE have increased plasma levels of vascular endothelial growth factors and angiopoietins (Angs), which have been associated with vascular permeability in several diseases. Among these and other factors, blood endothelial cells and vascular permeability can be modulated by extracellular or secreted phospholipases A₂ (sPLA₂s).

Objective

We sought to investigate the enzymatic activity and biological functions of sPLA₂ in patients with C1-INH-HAE.

Methods

sPLA_2<

SUBMITTER: Loffredo S 

PROVIDER: S-EPMC6064723 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature