Variable Effect of HIV Superinfection on Clinical Status: Insights From Mathematical Modeling.

ABSTRACT: HIV superinfection (infection of an HIV positive individual with another strain of the virus) has been shown to result in a deterioration of clinical status in multiple case studies. However, superinfection with no (or positive) clinical outcome might easily go unnoticed, and the typical effect of superinfection is unknown. We analyzed mathematical models of HIV dynamics to assess the effect of superinfection under various assumptions. We extended the basic model of virus dynamics to explore systematically a set of model variants incorporating various details of HIV infection (homeostatic target cell dynamics, bystander killing, interference competition between viral clones, multiple target cell types, virus-induced activation of target cells). In each model, we identified the conditions f

SUBMITTER: Moreh A 

PROVIDER: S-EPMC6064737 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature