Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease.

ABSTRACT:

Background

Endothelial microparticles are associated with chronic kidney disease (CKD) and complement activation. We hypothesized that the complement pathway is activated in patients with CKD via endothelial microparticles and that complement activation correlates with endothelial dysfunction in CKD.

Methods and results

We analyzed complement data of 30 healthy subjects, 30 patients with stage III/IV CKD, and 30 renal transplant recipients with stage III/IV CKD, evaluating the potential correlation of complement fragments with brachial artery flow-mediated dilation, Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and urinary albumin/creatinine ratio. Endothelial microparticles were characterized via proteomic analysis and compared between study

SUBMITTER: Jalal D 

PROVIDER: S-EPMC6064828 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature