Phenotypes of Pregnant Women Who Subsequently Develop Hypertension in Pregnancy.

ABSTRACT:

Background

Hypertensive disorders complicating pregnancy are a major cause of maternal death. Our objective was to evaluate maternal clinical, hemodynamic, and placental prognostic indicators in a consolidated manner to identify women who develop hypertension in pregnancy.

Methods and results

Twenty-six normotensive pregnant women from a specialized Placenta Clinic at increased risk of developing de novo hypertension and 20 normotensive healthy pregnant controls were recruited at 22 to 26 weeks' gestation. Fourteen maternal clinical, hemodynamic, and placental characteristics were assessed in the second trimester and aggregated. Principal component analysis of this combined data set determined that 3 dimensions accounted for 56% of the cohort variability. The first dimension

SUBMITTER: McLaughlin K 

PROVIDER: S-EPMC6064839 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature