Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults.

ABSTRACT:

Background

Left ventricular (LV) hypertrophy is associated with cerebrovascular disease and cognitive decline. Increased LV mass index is a subclinical imaging marker that precedes overt LV hypertrophy. This study relates LV mass index to white matter microstructure and cognition among older adults with normal cognition and mild cognitive impairment.

Methods and results

Vanderbilt Memory & Aging Project participants free of clinical stroke, dementia, and heart failure (n=318, 73±7 years, 58% male, 39% mild cognitive impairment) underwent brain magnetic resonance imaging, cardiac magnetic resonance, and neuropsychological assessment. Voxelwise analyses related LV mass index (g/m²) to diffusion tensor imaging metrics. Models adjusted for age, sex, education, race/et

SUBMITTER: Moore EE 

PROVIDER: S-EPMC6064880 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature