Discovery of an Experimental Model of Unicuspid Aortic Valve.

ABSTRACT:

Background

The epithelial growth factor receptor family of tyrosine kinases modulates embryonic formation of semilunar valves. We hypothesized that mice heterozygous for a dominant loss-of-function mutation in epithelial growth factor receptor, which are Egfr^Vel/+ mice, would develop anomalous aortic valves, valve dysfunction, and valvular cardiomyopathy.

Methods and results

Aortic valves from Egfr^Vel/+ mice and control mice were examined by light microscopy at 2.5 to 4 months of age. Additional Egfr^Vel/+ and control mice underwent echocardiography at 2.5, 4.5, 8, and 12 months of age, followed by histologic examination. In young mice, microscopy revealed anatomic anomalies in 79% of Egfr^<

SUBMITTER: Weiss RM 

PROVIDER: S-EPMC6064885 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature