Systems genetic analysis of inversion polymorphisms in the malaria mosquito Anopheles gambiae.

ABSTRACT: Inversion polymorphisms in the African malaria vector Anopheles gambiae segregate along climatic gradients of aridity. Despite indirect evidence of their adaptive significance, little is known of the phenotypic targets of selection or the underlying genetic mechanisms. Here we adopt a systems genetics approach to explore the interaction of two inversions on opposite arms of chromosome 2 with gender, climatic conditions, and one another. We measure organismal traits and transcriptional profiles in 8-d-old adults of both sexes and four alternative homokaryotypic classes reared under two alternative climatic regimes. We show that karyotype strongly influences both organismal traits and transcriptional profiles but that the strength and direction of the effects depend upon complex inter

SUBMITTER: Cheng C 

PROVIDER: S-EPMC6064990 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature