Anomalous diffusion, spatial coherence, and viscoelasticity from the energy landscape of human chromosomes.

ABSTRACT: The nucleus of a eukaryotic cell is a nonequilibrium system where chromatin is subjected to active processes that continuously rearrange it over the cell's life cycle. Tracking the motion of chromosomal loci provides information about the organization of the genome and the physical processes shaping that organization. Optical experiments report that loci move with subdiffusive dynamics and that there is spatially coherent motion of the chromatin. We recently showed that it is possible to predict the 3D architecture of genomes through a physical model for chromosomes that accounts for the biochemical interactions mediated by proteins and regulated by epigenetic markers through a transferable energy landscape. Here, we study the temporal dynamics generated by this quasi-equilibrium energy la

SUBMITTER: Di Pierro M 

PROVIDER: S-EPMC6065008 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature