Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.

ABSTRACT: Neocortical pyramidal neurons express several distinct subtypes of voltage-gated Na⁺ channels. In mature cells, Na_v1.6 is the dominant channel subtype in the axon initial segment (AIS) as well as in the nodes of Ranvier. Action potentials (APs) are initiated in the AIS, and it has been proposed that the high excitability of this region is related to the unique characteristics of the Na_v1.6 channel. Knockout or loss-of-function mutation of the Scn8a gene is generally lethal early in life because of the importance of this subtype in noncortical regions of the nervous system. Using the Cre/loxP system, we selectively deleted Na_v1.6 in excitatory neurons of the forebrain and characterized the excitability of Na_v1.6-deficient layer 5

SUBMITTER: Katz E 

PROVIDER: S-EPMC6065046 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature