Early Proteinuria Lowering by Angiotensin-Converting Enzyme Inhibition Predicts Renal Survival in Children with CKD.

ABSTRACT: Background Although pharmacotherapeutic proteinuria lowering was found to be nephroprotective in adults, the predictive value of early drug-induced proteinuria reduction for long-term renal survival in pediatric CKD is unknown. We analyzed data from the ESCAPE Trial for a potential association between initial antiproteinuric effect of standardized angiotensin-converting enzyme (ACE) inhibition and renal disease progression in children with CKD.Methods In total, 280 eligible children with CKD stages 2-4 (mean age 11.7 years old, median eGFR 46 ml/min per 1.73 m², 71% congenital renal malformations) received a fixed dose of ramipril (6 mg/m² per day) and were subsequently randomized to conventional or intensified BP control. We assessed initial proteinuria

SUBMITTER: van den Belt SM 

PROVIDER: S-EPMC6065076 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature