Interleukin-10 Producing Regulatory B Cells Transformed CD4⁺CD25^- Into Tregs and Enhanced Regulatory T Cells Function in Human Leprosy.

ABSTRACT: Regulatory B cells (Bregs) are known to exhibit their regulatory functions through interleukin-10 (IL-10) cytokine which suppress inflammation. There are only a few studies explaining the phenotype and functioning of these cells in contribution to host immunity in leprosy. Here, we evaluated the role of IL-10 producing Bregs in the pathogenesis of leprosy and assessed their immunoregulatory effects on Tregs and effector T cells. We found an increased frequency of Bregs and increased expression of their immune modulatory molecules (IL-10, FoxP3, and PDL-1) in leprosy patients. The potential immunoregulatory mechanism of Bregs was also investigated using MACS sorted Teff (CD4⁺CD25^-) and Treg (CD4⁺CD25⁺) cells were cocultured with Bregs to elucidate

SUBMITTER: Tarique M 

PROVIDER: S-EPMC6065098 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature