The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses.

ABSTRACT: Loss of barrier integrity has an important role in eliciting type 2 immune responses, yet the molecular events that initiate and connect this with allergic inflammation remain unclear. We reveal an endogenous, homeostatic mechanism that controls barrier function and inflammatory responses in esophageal allergic inflammation. We show that a serine protease inhibitor, SPINK7 (serine peptidase inhibitor, kazal type 7), is part of the differentiation program of human esophageal epithelium and that SPINK7 depletion occurs in a human allergic, esophageal condition termed eosinophilic esophagitis. Experimental manipulation strategies reducing SPINK7 in an esophageal epithelial progenitor cell line and primary esophageal epithelial cells were sufficient to induce barrier dysfunction and tra

SUBMITTER: Azouz NP 

PROVIDER: S-EPMC6065103 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature