Copy number variations in Friesian horses and genetic risk factors for insect bite hypersensitivity.

ABSTRACT:

Background

Many common and relevant diseases affecting equine welfare have yet to be tested regarding structural variants such as copy number variations (CNVs). CNVs make up a substantial proportion of total genetic variability in populations of many species, resulting in more sequence differences between individuals than SNPs. Associations between CNVs and disease phenotypes have been established in several species, but equine CNV studies have been limited. Aim of this study was to identify CNVs and to perform a genome-wide association (GWA) study in Friesian horses to identify genomic loci associated with insect bite hypersensitivity (IBH), a common seasonal allergic dermatitis observed in many horse breeds worldwide.

Results

Genotypes were obtained using the Axiom® Equine

SUBMITTER: Schurink A 

PROVIDER: S-EPMC6065148 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature