Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability.

ABSTRACT: In Drosophila, ubiquitous expression of a short Cyclin G isoform generates extreme developmental noise estimated by fluctuating asymmetry (FA), providing a model to tackle developmental stability. This transcriptional cyclin interacts with chromatin regulators of the Enhancer of Trithorax and Polycomb (ETP) and Polycomb families. This led us to investigate the importance of these interactions in developmental stability. Deregulation of Cyclin G highlights an organ intrinsic control of developmental noise, linked to the ETP-interacting domain, and enhanced by mutations in genes encoding members of the Polycomb Repressive complexes PRC1 and PR-DUB. Deep-sequencing of wing imaginal discs deregulating CycG reveals that high developmental noise correlates with up-regulation of genes involved in

SUBMITTER: Dardalhon-Cumenal D 

PROVIDER: S-EPMC6065198 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature