Differences in brain pathological changes between rotenone and 6-hydroxydopamine Parkinson's disease models.

ABSTRACT: Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson's disease animal models. They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra, but also satisfy the requirements for iron deposition. However, few studies have compared the characteristics of these two models by magnetic resonance imaging. In this study, rat models of Parkinson's disease were generated by injection of 3 μg rotenone or 10 μg 6-hydroxydopamine into the right substantia nigra. At 1, 2, 4, and 6 weeks after injection, coronal whole-brain T2-weighted imaging, transverse whole-brain T2-weighted imaging, and coronal diffusion tensor weighted imaging were conducted to measure fractional anisotropy and T2^* values at the injury site. The fractional anisot

SUBMITTER: Liu LX 

PROVIDER: S-EPMC6065241 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature