Transcriptome profiling of whisker follicles in methamphetamine self-administered rats.

ABSTRACT: Methamphetamine (MA) is a highly addictive psychostimulant that disturbs the central nervous system; therefore, diagnosis of MA addiction is important in clinical and forensic toxicology. In this study, a MA self-administration rat model was used to illustrate the gene expression profiling of the rewarding effect caused by MA. RNA-sequencing was performed to examine changes in gene expression in rat whisker follicles collected before self-administration, after MA self-administration, and after withdrawal sessions. We identified six distinct groups of genes, with statistically significant expression patterns. By constructing the functional association network of these genes and performing the subsequent topological analysis, we identified 43 genes, which have the potential to regulate MA re

SUBMITTER: Song SH 

PROVIDER: S-EPMC6065325 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature